Science news articles about 'k ras'

... 35% of colorectal cancers. These mutations keep K-Ras stuck in its active form, switching ... Leuven in Belgium will present data on the impact of K-Ras mutations from the Crystal study, in which patients ...

... treatment with Herceptin. In addition, data was recently presented showing the importance of testing for the K-ras gene to assess the clinical benefit of Erbitux for metastatic colorectal cancer. Of ...

... patients. In an additional analysis of the biomarkers EGFR and K-ras mutations, the study indicates that both ... ras gene mutation proved to be an overall poor prognostic marker, with both treatment arms ...

... tested the PI3K inhibitor in mice with K-Ras-stimulated tumors. That treatment was ineffective, but since K- ... combined treatment with both agents caused the K-Ras-stimulated lung tumors to virtually ...

... pancreatic cancer. Scientists already knew that a mutation in the K-RAS gene underlies the abnormal, excessive ... attractive new target for novel anti-RAS and anti-cancer therapy in pancreatic cancer, ...

... Settleman's group identified two classes of cancer cells: K-Ras mutant dependent ... groups and identified genes that are specifically upregulated in K-Ras-dependent cells and required for their viability ...

... resistant to treatment with radiation and have a poor prognosis. K-RAS mutations lead to the activation of networks ... exists for NSCL cancer tumors that harbor K-RAS mutations," Dr. Scaglioni said. Dr ...

... , mature pancreatic cells, such as insulin-secreting cells, became cancerous only when they expressed K-ras and also suffered from chronic inflammation. Under these conditions, the insulin-secreting ...

... engineered to spontaneously develop lung cancer when their K-Ras gene is activated with mice whose ... a genetic deletion of FAP and expressing an activated K-Ras gene. The Wistar team found that lung ...