... – of using pEGFR is that of personalized medicine, says Dr. Pandey. Obviously a growth factor receptor that is activated only in a subset of all pancreatic cancers cannot be a one-size-fits-all target ...
New research casts the role of a neuronal growth factor receptor -- long suspected to facilitate the toxic effects of beta amyloid in Alzheimer's disease -- in a new light, suggesting the molecule ...
... cancer. Knowing how Argos neutralizes tumor growth may lead to new drug designs for inhibiting ... molecule that activates the vascular endothelial growth factor receptor and several drugs can block tumor ...
... that alcohol can also cause brain injury and degeneration by inhibiting insulin and insulin-like growth factor. A new study using postmortem human brain tissue has found that chronic alcohol abuse ...
... is the first drug that specifically targets the receptor for these growth factors without cross-reacting with the closely ... IGF-1 and IGF-2 binding factors 1 and 2. It also completely inhibited ligand- ...
... were looking for chemicals that could imitate a protein in the brain known as NGF (nerve growth factor).
NGF has been used experimentally to treat Alzheimer's disease and the degeneration of nerves ...
... tracks.
Constructing tracks made from the repulsive factor sensed by ephrin-A, the researchers confirmed that axons ... signal by itself and instead requires the co-receptor p75," summarizes Yoo-Shick Lim ...
... the optic nerve wire up to the brain in a highly dynamic way. Using the mouse visual system, scientists have identified an unanticipated factor that helps keep retinal axons from going astray.
... form, targets proteins involved in angiogenesis, the growth of new blood vessels that has a critical role ... pazopanib targets include vascular endothelial growth factor receptor (VEGFR), platelet-derived ...
... cells that did not differentiate using a protein marker called KDR, a growth factor receptor expressed on the surface of the progenitor cells.
Once isolated, the cardiovascular progenitor cells ...
Scientists have uncovered a previously unrealized mechanism by which the epidermal growth factor receptor (EGFR), a tyrosine kinase, promotes survival of cancer cells through a kinase-independent ...
... that predispose women to breast cancer. Previous work showed that variants in the gene called fibroblast growth factor receptor 2 (FGFR2) were associated with increased risk of the ...
... and radiation treatments, while tumors that express high levels of a certain growth factor receptor are the least responsive and most deadly.
The researchers call these and other markers a promising ...
... Smith and colleagues demonstrate that mice lacking the fibroblast growth factor receptor 1 (FGFR1) display profound, non-habituating hyperactivity that is correlated with a lack of ...
... class of drugs known as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, ... percent of women with breast cancer are hormone receptor positive and Her-2 negative, said Cristofanilli. ...
