... anticipates that the newly discovered SLC45A3-ELK4 gene fusion may be added to that urine test in the future ... trials in the United States and Europe.
Novel Gene Fusion Sheds Light on How Cancer Works ...
... target for drug therapies.
"The prostate cancer gene fusions, and proteins they produce, are important because ... Dr. Rubin's team used state-of-the-art gene sequencing tools to discover the new class ...
Researchers have discovered a new gene fusion that is highly expressed in a subset of prostate cancers.
... In the current study, the researchers showed that newer techniques could identify these gene fusions more quickly and easily.
The researchers used a technique called gene sequencing, which involves ...
... parts of two different genes have merged to form one gene. Fusion genes are translated into abnormal ... normally requires damage to several different genes before cancer cells develop, and this usually ...
... pathologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.
"Interfering with this gene fusion -- or its downstream molecular pathways -- will be crucial in the search for drugs that ...
... fusions," adds senior author Arul Chinnaiyan, M.D., Ph.D., director ... prostate cancer. Chinnaiyan's discovery demonstrated that these gene fusions could be found in solid tumors and has opened an entire ...
... subtypes that are not well understood. "We know that ETS gene fusions occur in 40%-80% of prostate- ... oncogenes and downstream targets play a role in fusion-negative cancers," explains lead author, Dr. ...
... sites where chromosome segments reattach, genes fuse giving rise to chimeric RNA ... might be common in other normal tissues, because gene fusions have been identified in cancers that arise in many tissues ...
... , prostate cancer patients who carry the T allele of Met160Val are more likely to have a prostate tumor with the gene fusion than patients who have the C allele.
To find out if the T allele is ...
... evolution by the addition of C-Ala. They then came together with the aminoacylation function through gene fusion."
Guo and Schimmel decided to figure out the function of C-Ala.
A Bridge Between ...
... in pathology at the U-M Medical School.
The researchers believe the findings could have implications for gene fusions that occur in other cancer types. By understanding how gene fusions occur, the ...
