... , reported that New World owl monkeys (Aotus genus) make a fusion protein - AoT5Cyp - that potently blocks HIV-1 infection. The human genome encodes the equivalent of the 2 components ...
... leukemia. VIB researchers connected to the Katholieke Universiteit Leuven have discovered that the carcinogenic property of the fusion protein NUP214-ABL1 largely depends on its location in the cell. ...
Fusion proteins could offer a new tool for drug screening and biosensors
... most common reasons to see a physician for evaluation. Among various treatment options is spinal fusion surgery, which may use a biological agent known as bone-morphogenetic protein (BMP). read more
... exciting, because unlike two previous fusions co-discovered by the same Weill Cornell ... drug therapies.
"The prostate cancer gene fusions, and proteins they produce, are important because they serve ...
... . PML is commonly associated with acute promyelocytic leukemia (APL), in which it leads to the formation of a fusion protein that blocks cell differentiation.
After ascertaining that PML was highly ...
... upregulation of the oncogene ABL1 and the BCR-ABL1 oncogenic fusion protein in various mouse and human hematopoietic malignancies. Further, restoration of miR-203 resulted in a ...
... in the journal Nature Structural and Molecular Biology, describes the structure of the viral fusion protein gp64, which is involved in the mechanism which viruses use to invade host cells. In the ...
... Low pH prompts the aptly named fusion protein, on the virus's outer membrane, to change ... replaced each of the five histidines of the TBEV fusion protein with alternative residues and observed the virus ...
... that abnormal histone modification, you might be able to reverse the tumorigenic properties of the fusion protein."
It appears this inhibition may be relatively simply to accomplish. The researchers ...
... of DOT1L to the promoters of MLL target genes may be a common feature of many oncogenic MLL fusion proteins. However, the extent of H3K79 methylation changes and the specificity of these epigenetic ...
... state, with disastrous consequences.
"The MLL-AF4 fusion protein is somehow targeted to a set of genes ... MLL patients, it seems the MLL-AF4 protein alters the normal chromatin state of the hematopoietic ...
... -calcium-response V antigens (rLcrV) and recombinant F1 (rF1) antigens either in equal amounts or as a fusion protein (rF1-rLcrV). In the study the researchers immunized cynomolgus ...
... protein splicing. In this process, a protein sequence (intein) is autocatalytically split off from a fusion protein generated in a cell culture. The difficulty: as well as a terminal cysteine group, ...
... with adalimumab or infliximab (monoclonal anti–TNF-α antibodies), etanercept (a fusion protein), the monotherapeutic agent anakinra, or when patients changed conventional disease-modifying anti- ...
