... When an excess of glutamate collects in the synapse, the result is glutamate toxicity or excitotoxicity. Ultimately, if glutamate is not cleared out of the synapse, neurons become damaged and die by ...
... the motor neurons that spark muscle movement, causing death. The event, called excitotoxicity, also occurs in other neurological diseases.
So on a more basic level, the study adds clout to the ...
... gene, which the research team believes may be associated with susceptibility to glutamate excitotoxicity and hearing loss.
It is the overexpression of glutamate that causes damage to the inner and ...
... A stroke or head injury kills large numbers of neurons through a process called excitotoxicity. A surge of the neurotransmitter glutamate jolts receptors such as the kainate receptor and stimulates ...
... ," he said. "In fact, we chemically blocked inhibitory circuts that unmasked the purely excitotoxic properties of PCB170."
PLoS - Biology study
In the collaborative study between researchers at ...
... neuronal cell death is surprising and suggests new therapeutic targets for conditions that involve excitotoxicity."
The findings of the MNI and UdeM study represent a paradigm shift from the main ...
... which contributes a cascading series of events that ultimately lead to a state called excitotoxicity and cell death.
One of the keys to identifying the function of HUMMR has been the appreciation ...
... that nerve cells eventually die because they are strongly overstimulated, a process called excitotoxicity. In animal experiments conducted in the laboratory of Professor Ulrich Eisel, Department of ...
... hypothesized that PIKfyve might be directing CaV1.2 degradation. Using glutamate excitation to simulate excitotoxic stress, the authors showed that CaV1.2 is internalized, associates with PIKfyve, and ...
... in high concentrations, glutamate becomes toxic-- over-exciting the neurons. Glutamate-induced excitotoxicity is known to exacerbate damage caused by brain injury, stroke and other neurodegenerative ...
... , can cause an overstimulation of glutamate receptors, including the NMDA receptor. Such excitotoxicity, the theory holds, can cause nerve-cell death and subsequent neurological dysfunction.
A class ...
... it also blocked the protective synaptic NMDA receptor activity.
"For a long time it's been known that excitotoxicity is an early marker of Huntington's disease," said Dr. Hayden. "However, now we ...
