... enabled researchers at Baylor College of Medicine in Houston to describe how the genetic message of estrogen receptor-alpha is regulated, a finding that could have implications for breast cancer. In a ...
... breast cancer by 44 percent, compared with women not taking the drug. Raloxifene is a selective estrogen receptor modulator (SERM), which might suggest that the drug would have a preferential effect ...
... show that breast cancer cells that are resistant to tamoxifen display few of the "alpha" estrogen receptors that the drug is designed to bind on to and inhibit, but many more "gamma" estrogen-related ...
... tamoxifen," Vertino says. "Development of new drugs that interfere with the methylation of the estrogen receptor may be an alternative way to treat those tumors."
Until recently, scientists thought ...
... Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers. ... -linked TMPRSS2-ERG transcript, via the estrogen receptor (ER)-alpha and ER-beta. ...
... a technique they developed that can quickly determine whether the target DNA is – or is not – bound by the estrogen-receptor complex, the team was able to screen a long list of potential therapeutic ...
... who was not involved in the study. "From a technology perspective, their technique to transfect the estrogen receptor is an exciting advance for researching steroid receptors in the brain."
Studying ...
... focused on the prefrontal cortex because it is rich in estrogen receptor beta (ER-beta), a protein ... stroke and blood clots in women taking estrogen alone, and a higher than average incidence of breast ...
... Mongolian gerbils stomach.
Specific bands for estrogen receptor (ER)-alpha (68 kDa ... because Mongolian gerbils sex steroid receptors have not been sequenced at the gene or protein levels. The detection ...
... therapy. All study participants had estrogen-receptor positive tumors that had spread to their bones, livers or lungs ... Half of the patients got a high dose of estrogen (30 milligrams a day) and half got ...
Estrogen-receptor positive metastatic breast cancer often develops resistance to conventional therapies that severely lower a woman's estrogen level. A group of researchers headed by a breast cancer ...
University of Cincinnati (UC) researchers have discovered that estrogen receptors are present in medulloblastoma—the most common type of pediatric brain tumor—leading them to believe that anti- ...
... analyze whether a first tumor's estrogen receptor and progesterone receptor content and the age or race ... -fold increase in risk of a second hormone-receptor negative breast cancer.
"Future research ...
... also explain why drugs like tamoxifen act on tumor cell growth. One argument is that once the estrogen receptors of the tumor cells are inhibited by the drug, the sex hormone can no longer promote ...
... participated in the study. All participants were originally diagnosed with estrogen receptor positive (ER ) breast tumors, ... a high 30-milligram daily dose of estrogen to a low 6-milligram daily dose, ...
