... heretofore elusive function of long palindromes in DNA replication. Mirkin's research was funded by the National ... during cell division, explaining why DNA palindromes are genomic weak spots."
The study ...
... molecule from double helix to hairpin-like formation, which causes replication to stall. Altered or stalled ... causes chromosomal breaking. But why does DNA replication stall?
In a Tufts University study ...
... stem cells turn into different cell types, there are dramatic corresponding changes to the order in which DNA is replicated and reorganized. The findings bridge a critical knowledge gap for stem cell ...
... molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers from the laboratory of Rockefeller University`s Michael O ...
... a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers have discovered a small molecule that stops the sliding ...
... complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA ... -initiation after repair. The roles of Ddk in controlling the DNA replication machinery for genome stability and fidelity ...
... ' mechanisms to detect replication blocks and trigger the instant 'restart' of DNA replication there," said Mirkin. "Are the CGG repeats causing the checkpoints to fail?"
With replication stalled, ...
PUBLIC MULTIMEDIA # 11664 ALIGN:right --> HOUSTON - Abnormalities in genes that repair mistakes in DNA replication may help identify people who are at high risk of developing pancreatic cancer, a ...
... appear to first influence hundreds of thousands of DNA pieces to regroup. Then, when no longer ... that copies itself ad nauseum, selfish DNA replicates and passes from parent to offspring for the sole ...
... drugs intended to kill cancer cells.
The DNA repair process that removes such toxic "lesions ... alkytransferase) to remove the alkyl group before DNA replicates. The protein essentially sticks a chemical ...
... occur at a different time in the life of a cell. DNA replication takes place as the cell is dividing ... base pairs. The two separating strands become the replication fork. On one strand, an enzyme called ...
... that insertions and deletions are formed mostly by errors taking place during DNA replication, but the team found that the mutations also can form by mechanisms related to recombination. "What's ...
... apart is a protein that ensures the smooth progression of DNA replication to the end of a chromosome. The research, led ... hard to study because no specific DNA sequence preceeds or follows them," she ...
... in a slightly underwound state and its status changes in waves generated by normal cell functions such as DNA replication, transcription, repair and recombination. DNA is also accompanied by a cloud ...
... from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their ...
