... X-rays, but also occur during cell division, when DNA molecules split and form two new DNA ... a cancerous cell.
One major DNA-repair mechanism involved in repairing these breaks is known as homologous ...
... tumors can become resistant to chemotherapy by using DNA repair mechanisms to keep the cells alive. Drugs ... Rad51 protein causing it to fall off the DNA.
"Scientists had assumed that as Srs2 moved along ...
... are such a fundamental aspect of biology, but also because problems in the cycle and its DNA repair mechanisms can lead to mutations that cause the unchecked proliferation of cells associated with ...
... new targets for anti-cancer drugs that interfere with DNA repair, says Paul Doetsch, PhD, professor ... (cells' miniature power plants) have their own DNA.
Working with Doetsch, Emory graduate students ...
Some DNA repair enzymes can relocate to the part of the cell that needs their help, a team of scientists has found. The signal that prompts relocation is oxidative stress, an imbalance of cellular ...
... lead to cancer. Thanks to our body's DNA repair mechanisms, however, the effects of many carcinogens can be reversed ... de Montréal.
"NER is a critical DNA repair system that removes pieces of damaged ...
... checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. There are two branches ... result indicated that HBV induces cellular DNA damage response dependent on ATR but escapes ...
... genomic guardian posts and aid the DNA repair mechanism at the site of damage.
During this unguarded ... damage. As mice age, however, rates of DNA damage (typically caused by degrading mitochondria) ...
... adduct onto guanine.
But that is where DNA repair mechanisms come in, which is good in the case of chemicals ... protein called AGT (O6-alkylguanine DNA-alkytransferase) to remove the alkyl group before ...
... new light on a process that fixes breaks in the genetic material of the body's cells. Their findings could lead to ways of enhancing chemotherapy drugs that destroy cancer cells by damaging their DNA.
... his students, Chung-Wei Lee. They showed that mice infected with H. pylori, who also lacked the proper DNA repair mechanisms, were more susceptible to pre-cancerous lesions in the ...
... of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. There are two branches in ... ATM-Rad3-related (ATR). Many viruses are now known to interact with DNA damage sensing ...
... of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. There are two branches in ... HBV infection triggered an ATR-dependent DNA damage response, resulting in increased ATR ...
... feature of how DNA strand breaks can be handled. Their unexpected findings have important implications for the understanding of DNA repair mechanisms (Molecular Cell 33, 13 February 2009)...
... study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and ...
