... the lab, 'When we depleted CENP-N in cells, the centromere did not assemble correctly and chromosomes segregated abnormally, leading to situations similar to cancer'.
This study, the first paper from ...
Scientists have described the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division.
... -related disorders. Likewise, genetic diseases such as Down's syndrome result from improper chromosome segregation.
Mitosis, Hunt says, is one of the most important targets of chemotherapy.
"By ...
... to Tran, the findings have potential implications for cancer biology, in that inappropriate chromosomal segregation can lead to aneuploidies (cells lacking the proper number of chromosomes), which is ...
... cell must contend with two sets of chromosome pairs, homologs and sisters," he said. "Homologs ... interact with Pds5 during meiosis to regulate chromosome segregation and homolog synapsis," he said. "Long ...
... show that loss of CHFR disrupts normal chromosome segregation in breast cells during cell ... cancer-prone cells containing too many chromosomes. The fact that the spindle is affected is important, because ...
... a possible biomarker test for the detection of bladder cancer.
Aurora kinase A is a key regulator of chromosome segregation during cell division. Overexpression of this protein is common in cancers, ...
... protein enzyme, BubR1, helps make sure chromosomes are equally distributed during mitosis might ... by playing a risky evolutionary gamble. Improper chromosomal segregation allows cancer cells to shuffle ...
... published in the journal Proceedings of the National Academy of Sciences.
"The correct timing of chromosome segregation during cell division is necessary to ensure normal, healthy growth," Wang ...
A group of Dartmouth researchers has found a new function for one of the proteins involved with chromosome segregation during cell division. Their finding adds to the growing knowledge about the ...
... acts early in cell division and MCAK acts later. This cooperation underlines the importance of proper chromosome segregation for the healthy life of all cells." Compton is also director of the Cancer ...
... Distinguished Young Investigator Grant for an in-depth study of the centromere—a locus of control that appears on each chromosome and that helps to regulate cell division and chromosome segregation.
... of the kinetochore. The kinetochore attaches the chromosome to a microtubule for chromosome segregation. It is essential that chromosome segregation is carried out with high fidelity, since errors in ...
... how "mismatches" originating from rapid evolution of DNA and proteins could lead to chromosome segregation defects and aneuploidy events that are sometimes precursors in transitions to cancer.
