... of proteins within living T cells. T cells play an essential role defending the ... as integrins, becomes involved. Integrins are also cell surface receptors, and act as adhesive hooks that allow the T ...
... preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing ... role of CB1 in apoptosis, showing that tumor cells with high CB1 expression were sensitive to apoptosis ...
... State and a coauthor on the study.
"The hypothesis we're testing is that binding of cell surface receptors to asbestos fibers triggers a signal event, which initiates the cancer," said Lower, also a ...
... compounds to block the effects of adenosine on neurons. Neurons have several types of cell-surface receptors that enable them to respond to adenosine, but only pharmacological blockade of the A1 ...
... Program in Cellular Neuroscience, Neurodegeneration and Repair.
When information arrives at the cell surface, receptors that decode this information are internalized by a process called endocytosis. ...
... and simple. In this case it is a transient switch in the overall shape of the contending cell surface receptor itself which activates the ADAM10 protease to communicate this change and its functional ...
... called thrombospondin-1 from binding to its cell surface receptor, called CD47, affords normal ... safe. Decreasing CD47 levels on tumor cells also could make them more sensitive to attack by the patient ...
... more directly. This approach may also preserve some of the good effects mediated by the cell surface receptor.
Using a wide range of scientific techniques and experimental methods, the team, led by ...
... been seen before in other drugs. "Most drugs target enzymes, which act on proteins, or cell surface receptors, which proteins bind to," he says. "These agents work on the structure, or substrate, of ...
... new target for autoimmune disease treatment – a cell-surface receptor called DR3. Their research in mice, ... .
While closely related to TNFR1, DR3 is expressed in T cells, a different kind of immune ...
... may be inadvertently improving insulin sensitivity and likely many other abnormalities associated with cell surface receptors that have been unknowingly damaged by protease activation associated with ...
... -deficient mice transplanted with engineered T cells.
"By inducing mutations in the CCR5 gene using zinc ... gene. The CCR5 protein is one of the two cell-surface receptors needed for HIV to gain entry ...
... that mimics fibronectin, a protein in the body that acts as a binding site for cell surface receptors called integrins.
It is important to control the integrins binding to the titanium implant ...
... Transduction.
The tumor necrosis factor (TNF) receptor (TNFR) family codes for a large number of cell surface receptors of great biomedical importance, and its signaling mechanisms have been ...
... offers a paradigm for both kinase signaling in plants and for steroid signaling by cell-surface receptors in general. More importantly, the success of the proteomic methods demonstrated by Wang's ...
