... which is caused by a genetic defect similar to the one found in Huntington's, involves the same "deranged calcium signaling," researchers said.
Both SCA3 and Huntington's are caused by repeating ...
... are located on lysosomes and endosomes, which should change people's views of calcium signaling.
"It's as if we now understand that cells have not only a primary battery for calcium but other ...
... release and other essential functions. The researchers believe the findings will enhance the understanding of how calcium signals are regulated in cells and shed light on new ways to treat many ...
Scientists have found strong evidence that abnormal calcium signaling in neurons may play an important role in the development of spinocerebellar ataxia type 2 (SCA2), a disorder causing progressive ...
... beta generation, a hallmark of AD.
"We have discovered a mechanism that can account for altered calcium signaling in AD cells that involves a biochemical and functional interaction of FAD mutant PS ...
... reticulum called the inositol trisphosphate receptor [InsP3R], suggesting that it or other proteins in this calcium signaling pathway could be targets for new Alzheimer's disease therapies." The ...
Defective calcium metabolism in nerve cells may play a major role in a fatal genetic neurological disorder that resembles Huntington's disease, researchers have found in a mouse study.
... pathways.
CaM kinase II is a pivotal enzyme that registers changes in calcium levels and oxidative stress and translates these signals into cellular effects, including changes in heart rate, cell ...
... have identified a new family of proteins, TPC2 (two-pore channels), that facilitates calcium signaling from specialized subcellular organelles. The study, to be published April 22 in Nature, is the ...
... another research group at Karolinska Institutet, led by Professor Per-Olof Berggren, they also found that Calcium signaling in pancreatic beta-cells was reduced by the actions of the growth factor ...
... also an important step toward understanding the potential pathological cross talk between calcium signaling disturbances and pathways of amyloid-ß accumulation," the researchers concluded. "Moreover, ...
... secretion of insulin.
Optimal glucose-induced insulin secretion requires that the varying cAMP and calcium signals are coordinated in time. The study sheds new light on the cellular mechanisms that ...
... , Syt IV doesn't trigger neurotransmitter or hormone release.
"It does not simply translate a calcium signal into a command for hormone release," says Jackson. "Unlike other synaptotagmins, Syt IV ...
... when they are alone as opposed to clustered, and these differences help determine whether the calcium signal is "whispered" or "shouted".
Professor Taylor continued: "The IP3 receptors that we work ...
... cell to cell in a wave-like manner. These calcium waves travel relatively long distances ... insult. Our data support this hypothesis, but whether the calcium signals we observed actually protect or harm ...
