Science news articles about 'calcium release'
Mechanism explains calcium abnormalities in Alzheimer's brain
... Foskett and colleagues found that biochemical interactions of FAD mutant PS with an intracellular calcium release channel, called inositol trisphosphate receptor (InsP3R), profoundly increased channel ...Calcium may be the key to understanding Alzheimer's disease
... familial Alzheimer's disease disrupt the flow of calcium ions within neurons. The two proteins, ... PS2 (presenilin 1 and 2), interact with a calcium release channel in an intracellular cell compartment. ...'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find
... the cell as a whole. Normal ataxin-3 did not activate the channel or cause calcium release. The researchers also found that cells from a person with SCA3 showed abnormally high levels of calcium ...Researchers identify missing target for calcium signaling
... some time that NAADP, or nicotinic acid adenine dinucleotide phosphate, stimulates calcium release inside cells, but there was controversy about how this happened and where this calcium source was ...Prolonged stress sparks ER to release calcium stores and induce cell death in aging-related diseases
... death instead. The apoptotic machinery is triggered by calcium released from the ER, but how CHOP induces this step ... mice—known to suffer increased ER stress—showed elevated IP3R-dependent calcium ...Second genetic risk factor for late-onset Alzheimer's disease found
... the disease, where it acts as a channel for calcium, they show. Called calcium homeostasis modulator 1 ( ... early-onset Alzheimer's disease, linked to a calcium release ion channel. Those results appear ...Researchers unravel key mechanism of cellular damage in aging and disease
... , Dr. Cheng of Peking University, 15 years ago published a seminal study regarding local calcium release events, or calcium sparks," Dirksen said. "This study has been cited more ...Study could help target new pancreatitis treatments
... stores that allow calcium to enter the fluid inside pancreatic cells. They have also found that toxic calcium release can be significantly reduced if the gene responsible for the production of these ...Scientists shed new light on cause of inherited movement disorder
... colleagues demonstrated that the mutant ataxin-2 gene strongly associated with an intracellular calcium release channel, increasing the sensitivity of the channel to activation. They also found that ...
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