... at the Joslin Diabetes Center in Boston have found that a defect in the beta cells that make and release insulin has implications for the failure of these cells and the development of type 2 diabetes ...
... , we looked for factors that might contribute to the failing beta cell function in a cohort of women who we followed ... development, as well as look for genetics determinants of beta cell failure in Hispanic Americans in a separate ...
... of food into energy. By the time a diagnosis is made, most beta cells are destroyed beyond repair. Injections ... . Efrat, explaining that the next hurdle will be to "convince" these beta cells to produce insulin in the human body ...
... of Medicine, funded by JDRF, have discovered that adult beta cells have the ability to replicate with the help of a protein ... after the six week study and confirmed that the human beta cells replicated in the transplant model. "The question ...
... these screens to look for proteins that also might stimulate beta cell replication. The challenge now is to demonstrate ... identifying small molecules that may induce the expansion of beta cells, and it may help reveal the biological mechanisms ...
... numerous important processes in our bodies. One new example is miRNA-375. Without this molecule the beta cells in the pancreas degenerate, resulting in diabetes ...
... teams demonstrated for the first time that human beta cells could be induced to replicate by boosting levels ... effort to better understand the regulatory pathway of beta cell replication and to identify targets that might ...
... to be done to demonstrate the potential of these findings for human beta cell function and diabetes." To accelerate development ... . Those projects are screening for small molecules that promote beta cell regeneration, including compounds that can substitute ...
... in humans. "We were surprised by the impressive accumulation of Lkb1 in beta cells of diabetic mice, which suggested that Lkb1 ... to their impaired function. After removal of the Lkb1 gene, the beta cells grow larger, proliferate more, and secrete ...
... worldwide found that injections of the drug rituximab slowed beta cell destruction in the pancreas of those newly diagnosed ... to attack. Rituximab directly attacks and destroys the beta cells. For the current study, researchers conducted ...
... that cause inflammation and can lead to the death of beta cells in laboratory models. In fact, EVMS researchers ... human islets — the region of the pancreas that contains beta cells — from individuals who have donated their bodies to science ...
... of new research reveal that the insulin-producing beta cells can proliferate in patients recently diagnosed with type 1 diabetes and suggest that, in the future, an intervention ...
... how a polyunsaturated fatty acid, arachidonic acid, can positively impact on the function and survival of pancreatic beta-cells in the lipotoxic environment commonly associated ...
... in diabetes research is to discover molecules that stimulate beta cell growth and to find drugs that target ... , have done both, discovering not only a protein that regulates beta cell growth, but also a chemical compound that stimulates ...
... signal that prompts production of insulin-producing beta cells in the pancreas -- a breakthrough discovery that may ultimately ... se that is the signal, but the glucose-sensing capacity of the beta cell that's the key for regeneration." This was the first time ...
