Scientists at the Joslin Diabetes Center in Boston have found that a defect in the beta cells that make and release insulin has implications for the failure of these cells and the development of type ...
... looked for factors that might contribute to the failing beta cell function in a cohort of women who we followed ... weight gain appeared to negatively impact beta cell function in two ways—it worsened ...
... TAU's Sackler Faculty of Medicine, whose research group is among world leaders in beta ... Efrat, explaining that the next hurdle will be to "convince" these beta cells to produce insulin in the human body ...
... Medicine, funded by JDRF, have discovered that adult beta cells have the ability to replicate with the help of a protein ... human beta cell cycle progression, Dr. Stewart and his colleague provide new ...
... two ways: it is a step toward identifying small molecules that may induce the expansion of beta cells, and it may help reveal the biological mechanisms regulating beta cell expansion," said Patricia ...
... that short, noncoding RNAs regulate numerous important processes in our bodies. One new example is miRNA-375. Without this molecule the beta cells in the pancreas degenerate, resulting in diabetes.
... now shown in mouse experiments that knocking out two cell cycle proteins leads to robust ... effort to better understand the regulatory pathway of beta cell replication and to identify targets that might ...
... year (June 30, 2009).
"From minimal funding just a few years ago, beta ... done to demonstrate the potential of these findings for human beta cell function and diabetes."
To accelerate development ...
... cell function lasted for at least five months, even in mice fed a high-fat ... humans.
"We were surprised by the impressive accumulation of Lkb1 in beta cells of diabetic mice, which suggested that Lkb1 ...
... diabetes. "Evidence is growing that if there is an iron imbalance in the beta cells of the pancreas, these cells won't produce insulin properly," Thiele said. "Now we know what happens in ...
... the journal Laboratory Investigation. The researchers have shown in vitro that insulin-producing β-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This ...
... levels.
Recent research exploring a possible long-term treatment – the transplantation of insulin-producing beta cells into patients – has yielded promising results. But this approach faces its own ...
... that islet progenitor cells within the adult pancreas could be activated to increase the number of beta cells by the process of differentiation rather than self-duplication, but the paper did not ...
... for life.
A promising alternative to insulin injections is cellular transplantation, in which beta cells are harvested from cadavers and injected into the bloodstream of patients with diabetes; the ...
... lead to new therapies for preventing the death of β cells or restoring those that have already been lost, Kathrin Maedler ... body's first line of defense--can lead to beta cell failure in type II diabetes ...
