Scientists have discovered a previously unknown mechanism by which apolipoprotein E, a molecule whose mutation is linked to Alzheimer's disease (AD), stimulates degradation of sticky amyloid beta (A?) ...
Scientists have discovered a previously unknown mechanism by which apolipoprotein E, a molecule whose mutation is linked to Alzheimer's disease, stimulates degradation of sticky amyloid beta protein ...
... a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. In ...
... a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response (in vivo).
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... abusers and found that heavy marijuana users show increased levels of a protein called apolipoprotein CIII which can cause increases in blood triglyceride levels. These findings might explain why ...
... that the "alternative splicing" also accounted for 15 percent of the reduced response of apolipoprotein B — a constituent of LDL — to simvastatin and 6 percent of the lower triglyceride response to ...
... of HIV-associated dementia.
"A large body of evidence suggests that the amphipathic helical domains of apolipoproteins act as fusion inhibitors," said Dr. Mahley. "We speculate that these domains in ...
... , compared with controls, the authors reported. They included transthyretin, clusterin, albumin, and apolipoprotein A-1 (apoA1).
If the results translate to humans, these proteins have the potential ...
... Lipid Research. In fact, all 11 subjects who carried both copies of this rare variant for apolipoprotein A-V had extremely high and dangerous triglyceride levels in their blood. Apolipoprotein A-V is ...
... cholesteryl ester transfer protein (CETP) gene are associated with increases in HDL-C whereas mutations in the apolipoprotein (apo) AI gene (the major apolipoprotein of HDL particles), or the lecithin ...
... whether they carried the most powerful genetic indicator for Alzheimer's -- the epsilon 4 allele of apolipoprotein E. In the current study, the effects of this allele were controlled for, yet similar ...
... salicylate– can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 ...
... recently published research, Dichek and his team bred transgenic mice that were deficient in Apolipoprotein E (and therefore had high cholesterol and triglyceride readings) and whose macrophages—the ...
... . 13 by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4. People who carry two copies of the gene have roughly eight to 10 ...
... 2 (PTGS2), which produces prostaglandins, compounds that cause inflammation. Variants of a third gene, apolipoprotein E1 (ApoE1), which helps break down and remove triglycerides from the blood and ...
