Science news articles about 'amyloid diseases'

... of the 30 or so proteins that form amyloid in human disease, our results show that the fibres they produce ... such as Parkinson's and Alzheimer's, whereas in other amyloid diseases deposits can be found elsewhere in the body, in the joints, liver and many other organs ...

... agent targeting the underlying cause of a human amyloid disease —was built on years of basic scientific ... , when incorporated into a TTR protein otherwise composed of amyloid disease-associated TTR subunits, prevents ...

... Biology. This perspective may also have implications for conditions as diverse as type II diabetes, arthritis, osteoporosis, and amyloid disease (including Alzheimer's). While in many genetic ...

... a fundamental step in the search for therapies for amyloid-related diseases such as Alzheimer's, Parkinson's and diabetes mellitus ... , but in our fundamental understanding of how amyloid fibres may form in other diseases as well. Many amyloid diseases are due to changes ...

... is published in a recent issue of Nature Chemistry. The amyloid diseases are characterized by plaque that aggregates into toxic ... new avenues for investigating the pathogenic mechanisms of amyloid diseases, their early diagnosis and eventual treatment ...

... —through "misfolding"—then aggregating to form amyloid plaques in the brain. "Ever since the 'mad ... should prove beneficial in understanding the origins of other amyloid diseases such as Alzheimer's, Parkinson's, and rheumatoid arthritis ...

... of structure-based drugs designed against amyloid diseases," said Eisenberg, who is a UCLA professor of chemistry ... the idea that the structure-based design of therapeutics for amyloid diseases is a plausible option. Despite this success ...

... the hundreds of thousands of people who have TTR-related amyloid diseases or are at risk for them, and may have advantages over other TTR ... with aging," said Graef. Apparently for that reason, TTR amyloids are found at autopsy in the heart and other organs of 10 to 15 ...