... regenerative medicine, scientists have discovered that a trick used by tumor cells that allows them to migrate around the body can cause normal, adult cells to revert into stem cell–like cells. [More]
... by inserting a set of four genes into these skin cells. While the study was a powerful proof-of-principle, ... safer ways to generate stem cells from adult cells -- developing methods that require fewer ...
Researchers have succeeded for the first time in reprogramming clearly defined adult cells into pluripotent stem cells -- directly and without viruses.
... at the Harvard Stem Cell Institute (HSCI), and at the Whitehead Institute that they had each — independently — coaxed adult cells into reverting to an embryonic stem cell-like state was arguably the ...
... sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells ...
Adult cells of mice created from genetically reprogrammed cells—so-called induced pluripotent stem (IPS) stem cells—can be triggered via drug to enter an embryonic-stem-cell-like ...
... differentiate them into motor neurons.
Scientists had originally hoped to create neurons and other adult cells using "therapeutic cloning," in which DNA from a patient is inserted into a donated ...
... based treatments created from their own adult cells. However, Eggan believes that the first therapeutic ... risks that were taken in forming the Harvard Stem Cell Institute will ultimately pay off for both ...
... c-Myc, one of four genes added to adult cells to reprogram them to an embryonic-stem- ... whose overexpression can also cause cancer. For IPS cells to be employed to treat human diseases such as Parkinson ...
... stem cell circuitry. With this map, the scientists have moved one step closer to understanding how adult cells can be reprogrammed to an embryonic state and then to other types of cells, and to ...
... core facility funded by the Harvard Stem Cell Institute. Daley and his colleagues published ... Daley and his colleagues' techniques for reprogramming adult cells are readily available so other researchers ...
... produce any type of specialized adult cells in the human body – use animal-based materials ... hESCs are considered promising sources for future cell therapy to treat diseases such as Parkinson's disease ...
... of regenerative medicine on its head, Harvard Stem Cell Institute (HSCI) co-director Doug Melton ... of developmental biologists – directly turning one type of fully formed adult cell into another type of ...
... explored.
Unlike SCNT, iPS cells are derived from adult cells, such as skin, which are reprogrammed to behave ... allow him to create human iPS cells in Australia for the first time.
"On paper, iPS ...
... give rise to any other fetal or adult cell type, and then inducing them to differentiate, ... specific proteins that control which genes are active in a cell), a technique pioneered by Dr. Shinya Yamanaka ...
