Ovarian cancer clue: Methylation-mediated suppression of a key pathway is found

Ovarian cancer is the leading cause of death among gynaecological cancers. To better understand the disease and improve therapies, researchers are investigating how deregulation of genes across the genome could be contributing to malignancy. In a study published online today in Genome Research (www.genome.org), scientists have identified age-related gene-specific accumulation of DNA methylation that suppresses a critical cellular pathway contributing to ovarian carcinogenesis, information that will be crucial for future translational research...

Read the whole article on

More from