Integrin clusters are the universal units of cell adhesion
Wednesday, January 6, 2016 - 06:30
in Physics & Chemistry
Scientists from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore have discovered the universal building blocks that cells use to form initial connections with the surrounding environment. These early adhesions have a consistent size of 100 nanometres, are made up of a cluster of around 50 integrin proteins and are the same even when the surrounding surface is hard or soft. Deciphering the universal nature of adhesion formation may reveal how tumour cells sense and migrate on surfaces of different rigidity, which is a hallmark of metastasis, the devastating ability of cancer to spread throughout the body. This study was published in the 7 December 2015 issue of Developmental Cell.