Protein aggregation after heat shock is an organized, reversible cellular response

Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction. Reporting in Cell on Sept. 10, 2015, scientists from the University of Chicago and Harvard University discovered that aggregates are fully reversible - after the cell returns to normal temperatures, aggregated proteins are disentangled and resume their normal cellular functions. Some proteins were found to remain intact and even functional while in an aggregated state.

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