Statistician helps resolve dispute about how gene expression is controlled

The differences between different tissues, such as brain and muscle, and between healthy and unhealthy human cells are largely defined by changes in the abundance of proteins in the cells. Transcription—the process that governs the flow of genetic information from DNA to RNA—was long believed to play the dominant role in determining the quantity of proteins in a cell. But over the past decade, many studies have claimed that in animals, differences in the rate at which RNA is translated into proteins are a more important factor.

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