'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers
Friday, August 29, 2014 - 08:30
in Biology & Nature
In a cell's nucleus, chromosomal DNA is tightly bound to structural proteins known as histones, an amalgam biologists call chromatin. Until about two decades ago, histones were regarded as a nuclear "sidekick," the mere packing material around which the glamorous DNA strands were wrapped. Recently, however, biologists have developed a greater appreciation for how DNA/histone interactions govern gene expression.