New Life For First-Line Antibiotics

Researchers have identified a single, simple metric to guide antibiotic dosing that could bring an entire arsenal of first-line antibiotics back into the fight against drug-resistant pathogens. A computer simulation created by Hannah Meredith, a biomedical engineering graduate fellow at Duke University, revealed that a regimen based on a pathogen's recovery time could eliminate an otherwise resistant strain of bacteria. In theory, a database of recovery times for bacterial and antibiotic combinations could allow first-line antibiotics to clear many resistant infections. Work to create such a database is underway and early tests are confirming her model's predictions. read more

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