Mechanisms Of Cancer-causing Mutations Uncovered

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well-known "resistance" mutations in the gene called epidermal growth factor receptor (EGFR). While these mutations were known for quite a long time, the question as to why they cause cancer or make some drugs ineffective was still not answered. The study demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients. read more

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