Nrf2 - Antioxidant Protein Also Promotes Clogging Of Arteries

Why haven't antioxidant therapies yielded more positive results?   The answer may be that Nrf2, a protein that plays an important role in some antioxidant therapies, may not be as effective due to additional mechanisms that cause it to promote atherosclerosis - clogging of the arteries. Nrf2 has been thought to be an important drug-therapy target for diseases such as cancer because it can induce chemopreventive activity by attaching to specific sequences of DNA, leading to the release of numerous antioxidant and anti-inflammatory genes and enzymes that can decrease or inhibit the effects of carcinogens.  read more

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