New drug active against most aggressive type of lung cancer cells

A new drug could prove useful in treating small cell lung cancer -- the most aggressive form of lung cancer, researchers report. Scientists tested a drug -- known as AZD3965 -- on small cell lung cancer cells, with a focus on exploiting the change in energy production in tumors. In cancer cells, there is a switch to using glycolysis, a process that requires less oxygen and produces lactate as a by-product. Certain molecules -- monocarboxylate transporters (MCTs) -- are involved in the movement of lactate out of cells and drugs that target MCTs have been shown to stop tumor growth.

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