Reelin protein rescues cognitive deficits in an animal model of Alzheimer's disease

Reelin, a crucial protein for adult brain plasticity, recovers cognitive functions in mice with Alzheimer’s disease. This is one of the main results a new study. Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive deficits, synaptic loss and neuronal death. This new preclinical study demonstrates that an increase in Reelin brain levels avoids cognitive deterioration in mouse models of Alzheimer's disease. Moreover, Reelin delays amyloid-beta fibril formation in vitro and reduces amyloid deposits in mice with Alzheimer's.

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