Molecular glue controls chromosome segregation in oocytes

Most trisomic pregnancies arise as a consequence of chromosome missegregation in egg precursor cells called oocytes. Austrian researchers aim to understand the molecular causes of female age-dependent chromosome missegregation in oocytes. They have now discovered that a “molecular glue” called cohesin plays an important role in proper functioning of checkpoint control, ensuring correct chromosome segregation and production of euploid eggs.

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