How yeast protein breaks up amyloid fibrils and disordered protein clumps

Monday, November 19, 2012 - 22:31 in Biology & Nature

Hsp104, an enzyme from yeast, breaks up both amyloid fibrils and disordered clumps. For stable amyloid-type structures, Hsp104 needs all six of its subunits, which together make a hexamer, to pull the clumps apart. By contrast, for amorphous, non-amyloid clumps, Hsp104 required only one of its six subunits.

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