Biophysicists unravel secrets of genetic switch
Thursday, August 30, 2012 - 19:30
in Biology & Nature
Biophysicists have experimentally demonstrated, for the first time, how the nonspecific binding of a protein known as the lambda repressor, or C1 protein, bends DNA and helps it close a loop that switches off virulence. Findings are the first direct and quantitative determination of non-specific binding and compaction of DNA, relevant for the understanding of DNA physiology, and the dynamic characteristics of an on-off switch for the expression of genes.