Research could help people with declining sense of smell

Cells in the nose – smell sensors, primarily – are constantly replaced as old ones die off. Olfactory stem cells are the source for these new cells, but how do they determine when to form mature cells? Neuroscientists have now found a genetic trigger – a transcription factor – that acts as a brake on differentiation. Removing it makes stem cells change into mature olfactory cells at the expense of self-renewal.

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