Useful biomarkers for oesophageal squamous cell carcinoma

MicroRNAs (miRNAs) regulate gene expression by mainly binding to the 3'-UTR of target mRNAs, leading to mRNA degradation or translation inhibition. Oesophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China. Many studies have reported the miRNA expression profiles in Barrett's oesophagus and oesophageal adenocarcinoma. However, the pathobiological significance of aberrant miRNA expression in human ESCC has not been well documented...

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