Noninvasive MR imaging of blood vessel growth in tumours using nanosized contrast agents
Formation of new blood vessels, also known as angiogenesis, is crucial for sustained tumour growth and cancer metastasis. Recently, clinically available therapies to suppress the growth of these vessels have been available to improve patient survival in some cancer types. Accurate detection and quantification of blood vessel growth using nonsurgical methods would greatly complement current therapies and allow physicians to quickly assess treatment regimens and adjust them as necessary. In the work published in the August issue of Experimental Biology and Medicine, Kessinger and coworkers have incorporated nanotechnology, material science, and the clinical imaging modality MRI, to create a nanosized probe capable of noninvasively visualising and quantifying the blood vessel growth in tumours in a preclinical model. The work was carried out by Chase Kessinger, as part of his PhD thesis in cancer molecular imaging, working together with Jinming Gao and other colleagues, at the University of Texas Southwestern Medical...