The protein GRP78 opens the door to life-threatening fungal infection

Mucormycosis is a life-threatening infection most commonly caused by a species of fungus known as Rhizopus oryzae. It occurs predominantly in individuals with diabetes, in particular those with the potentially life-threatening complication known as diabetic ketoacidosis. A team of researchers, led by Ashraf Ibrahim, at the University of California Los Angeles, has now generated data in mice that provide an explanation as to why patients with DKA are highly susceptible to mucormyosis. The data also suggest a new avenue of research for those developing therapeutics for this life-threatening infection...

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