Discovery of epigenetic memory during breast cancer

Researchers from the Boston University School of Medicine (BUSM) have determined how the TGFbeta-Smad signalling pathway, which is over activated in late-stage cancers, is responsible for the 'epigenetic memory' that maintains unique patterns of regulatory DNA hypermethylation causing silencing of critical genes that facilitate breast cancer progression. The findings, which appear online in Cancer Research, may lead to the development of new therapeutic strategies for late stage breast and other cancers...

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