The Dark Side Of The Love Hormone Oxytocin

Tuesday, July 23, 2013 - 11:30 in Health & Medicine

New research shows oxytocin isn't the anti-anxiety drug we thought it was. Oxytocin, the feel-good bonding hormone released by physical contact with another person, orgasm and childbirth (potentially encouraging monogamy), might have a darker side. The love drug also plays an important role in intensifying negative emotional memories and increasing feelings of fear in future stressful situations, according to a new study. Two experiments performed with mice found that the hormone activates a signaling molecule called extracellular-signal-related kinases (ERK), which has been associated with the way the brain forms memories of fear. According to Jelena Radulovic, senior author on the study and a professor at Northwestern University's medical school, ERK stimulates fear pathways in the brain's lateral septum, the region with the highest levels of oxytocin. Mice without oxytocin receptors and mice with even more oxytocin receptors than usual were placed individually in a cage with aggressive mice to create a...

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