High-resolution mapping of cell types with improved single-cell sequencing

Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, methods generally suffer from low sensitivity and quantification that is limited to short RNA pieces. Now, researchers at Karolinska Institutet have released Smart-seq3 that greatly improves the quality in scRNA-seq. The study is published in Nature Biotechnology.

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