Study: Structure of biocatalysts depends on whether they are in cells or in the test tube

The structure of enzymes determines how they control vital processes such as digestion or immune response. This is because the protein compounds are not rigid, but can change their shape through movable "hinges." The shape of enzymes can depend on whether their structure is measured in the test tube or in the living cell. This is what physicochemists at the University of Bonn discovered about YopO, an enzyme of the plague pathogen. This fundamental result, which has now been published in the journal Angewandte Chemie, is potentially also of interest for drug research.

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