RNA degradation contributes to gene silencing in higher eukaryotes
Friday, April 24, 2020 - 09:11
in Biology & Nature
The Gasser group discovered that silencing of heterochromatic regions—and more specifically of hundreds of Polycomb-target genes enriched for H3K27me3—can occur through selective RNA degradation, and not only through transcriptional repression. The study links the epigenetics state of a gene with the fate of its RNA transcript. It is the first time that this is shown in higher eukaryotes.