Protecting DNA origami for anti-cancer drug delivery
Monday, March 9, 2020 - 14:20
in Biology & Nature
Scientists have designed and synthesized chains of molecules with a precise sequence and length to efficiently protect 3-D DNA nanostructures from structural degradation under a variety of biomedically relevant conditions. They demonstrated how these "peptoid-coated DNA origami" have the potential to be used for delivering anti-cancer drugs and proteins, imaging biological molecules, and targeting cell-surface receptors implicated in cancer. Their method for designing peptoids to stabilize DNA origami in physiological environments is described in a paper published in the Proceedings of the National Academy of Sciences the week of Mar. 9.