Research team finds possible new approach for sleeping sickness drugs

Using ultra-bright X-ray flashes, a team of researchers has tracked down a potential target for new drugs against sleeping sickness: The scientists have decoded the detailed spatial structure of a vital enzyme of the pathogen, the parasite Trypanosoma brucei. The result provides a possible blueprint for a drug that specifically blocks this enzyme and thus kills the parasite, as the team led by Christian Betzel from the University of Hamburg, Lars Redecke from the University of Lübeck and DESY, and Henry Chapman from DESY reports in the journal Nature Communications.

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