Molecular probe maps misfolded proteome state in live cells
Thursday, January 9, 2020 - 09:30
in Biology & Nature
The folding state of the proteins in live cells often reflect the cell's general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment. The fluorescence signal of the probe quantifies unfolding and its chameleon-like color shift maps the cellular regions of enhanced misfolding, says the study published in the journal Angewandte Chemie.