Distorted, stretched DNA may increase risk of off-target changes with CRISPR-Cas9
Tuesday, February 26, 2019 - 08:40
in Biology & Nature
Distortions to DNA, which occur routinely during gene expression and other cellular processes, could lead to off-target changes to the genome when using CRISPR-Cas9, a new study suggests. The Medical Research Council scientists behind the research say that their findings may help to pave the way to improve on the accuracy of gene editing for clinical applications.