Unveiling the mechanism protecting replicated DNA from degradation
Monday, October 1, 2018 - 06:50
in Biology & Nature
Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. They have gained unprecedented access to the underlying mechanism and determined that during DNA replication and cell proliferation in vertebrate cells, AND-1 has two different functions mediated by different domains of AND-1.