The best of both worlds: Basic-to-acidic flash switching for organic synthesis
Friday, August 3, 2018 - 09:30
in Physics & Chemistry
Scientists at Tokyo Institute of Technology developed a fast and practical technique using a micro-flow reactor for the synthesis of pure N-carboxy anhydrides (NCAs). They exploited the advantages of carrying out the synthesis under basic conditions and avoided its disadvantages by flash switching to acidic conditions after 0.1 seconds. This approach enabled them to produce several types of NCAs in a scalable, space-saving, and less time-consuming fashion.