Computer models could allow researchers to better understand, predict adverse drug reactions
Thursday, March 9, 2017 - 06:31
in Health & Medicine
New computer models from North Carolina State University show how a variant of a common protein involved in human immune response binds to the antiviral drug abacavir, causing a severe life-threatening reaction known as the abacavir hypersensitivity syndrome (AHS). The work has implications for predicting severe adverse reactions caused by existing drugs and future drug candidates in subpopulations of patients.