Thwarting autoimmune diseases: Unique binding modes of immunoproteasome inhibitors as basis for new drugs
Monday, November 28, 2016 - 12:31
in Biology & Nature
The immunoproteasome dismantles proteins and the resulting fragments are displayed on the surface of cells. This helps the immune system to recognize abnormal cells. However, in chronic inflammations and autoimmune diseases this "information channel" is overactive. Now researchers at the Technical University of Munich (TUM) have determined the molecular mechanisms of inhibitors that can selectively thwart the human immunoproteasome - important insights for the targeted development of new drugs.