Carbon-carbon bond formation at selective aliphatic carbon sites
Wednesday, November 2, 2016 - 08:32
in Psychology & Sociology
(Phys.org)—John C. K. Chu and Tomislav Rovis of Colorado State University and Columbia University have devised a strategy for C-C bond formation at inert tertiary C-H bonds of amides. This reaction involves cleavage of the C-H bond and subsequent coupling with an alkene. Their reaction works with a variety of amides and alkenes and is selective for a particular C-H among all seemingly indistinguishable C-H bonds. Their report appears in Nature.