Structure of mammalian protein complex of respiratory chain solved at atomic level
Wednesday, September 7, 2016 - 05:31
in Biology & Nature
The mitochondrial complex I plays a central role in cellular respiration and energy metabolism. The ~1 megadalton L-shaped protein complex is the largest protein assembly of the respiratory chain and now the largest asymmetric membrane protein assembly solved to date. Professor Leonid Sazanov and his British collaborators published the nearly complete atomic structure of the ovine (mammalian) mitochondrial complex I at 3.9 Å resolution, solved by cryo-electron microscopy aided by crosslinking/mass-spectrometry mapping in the scientific journal Nature.