Cellular "blindness" to chromosome cohesion defects
Wednesday, March 23, 2016 - 09:30
in Health & Medicine
Research led by Raquel Oliveira, group leader at Instituto Gulbenkian de Ciência (IGC; Portugal), has elucidated how cells are almost blind to chromosome cohesion defects. The results, published in the scientific journal Cell Reports uncovered how these defects, often associated with cancer development, congenital diseases and infertility, evade the strict surveillance of the checkpoint mechanisms that ensure faithful genome segregation.