How packing away DNA stabilizes cell fate decisions
Wednesday, December 2, 2015 - 10:45
in Physics & Chemistry
Susan Gasser and her group at the FMI have identified in C. elegans a much sought-for anchor protein, a previously uncharacterized chromodomain protein called CEC-4 that directly sequesters inactive chromatin at the nuclear membrane. In a study published in Cell, they described the mechanism of how CEC-4 contributes to the 3D organization of the nucleus, and identified a new paradigm for the contribution of nuclear anchoring towards stabilizing cell fate decisions.